Travelers to Brazil, especially in the Amazon and northeastern states, should consider vaccination against typhoid fever, caused by Salmonella Typhi. This article compares two primary typhoid vaccines: Vivotif, an oral vaccine, and Typhim Vi, an injectable option. Each has distinct advantages regarding efficacy, duration of protection, and suitability for different age groups and health statuses. Understanding these factors is vital for making informed health decisions before traveling to regions with higher typhoid risk. Effective prevention combines vaccination with careful food and water safety measures.